Author Topic: How the World’s First Dengue Vaccination Drive Ended in Disaster  (Read 738 times)

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How the World’s First Dengue Vaccination Drive Ended in Disaster
Is a runaway immune reaction making a dengue vaccine dangerous?

By Seema Yasmin, Madhusree Mukerjee on April 1, 2019

How the World's First Dengue Vaccination Drive Ended in Disaster

https://www.scientificamerican.com/article/how-the-worlds-first-dengue-vaccination-drive-ended-in-disaster/

In Brief

    A mosquito-borne disease, dengue affects almost 400 million people worldwide every year. Whereas most of those affected barely notice a first dengue infection, a second one can kill.

    A controversial old theory, called antibody-enhanced development (ADE), explains why a second dengue infection can be much deadlier than the first. New studies strongly support this theory.

    The first ever vaccine licensed for dengue appears to mimic an initial dengue infection, possibly exacerbating a second one. The role of ADE in driving this phenomenon remains contested.

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